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. 2020 Nov 20;13:135. doi: 10.1186/s13048-020-00741-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Biological Effects of STAT4 on cell cycle and PI3K signaling pathway in GCs. a Effects of pcDNA3.1-STAT4 on the cell cycle stage; b Effects of STAT4-siRNA on the cell cycle stage; c Relative mRNA expressions of PIK3CG, PI3C1, and PDK1 after the treatment by pcDNA3.1-KISS1; d Relative mRNA expressions of FOXO3, TSC2, and BAD after the treatment by pcDNA3.1-KISS1; e Effects of KISS1-siRNA on the relative mRNA levels of PIK3CG, PI3C1, and PDK1; f Effects of KISS1-siRNA on the relative mRNA levels of FOXO3, TSC2, and BAD. ** indicates P < 0.01; * indicates P < 0.05. Data were represented as means ± SD