FIGURE 1.

Molecular players involved in the mitochondrial cardioprotective response during IR that may be altered in aged cardiomyocytes. Supercomplex mitochondrial interactosome (MIt), consisting of mitochondrial ATP synthase, phosphate carrier (PiC), voltage‐dependent anion channel (VDAC), mitochondrial creatine kinase (MtCK), adenine nucleotide translocator (ANT), and respiratory chain complexes, is shown separately. AK, adenylate kinase; HK, hexokinase; IMS, intermembrane space; MIM, mitochondrial inner membrane; MOM, mitochondrial outer membranes; SR, sarcoplasmic reticulum