Table 1.
Patient | Sex/age (years) | Diagnosis/clinical stage | TSEBT dose | Concurrent therapy | Maintenance therapy | Acute toxicities D1–W6 | Sub-acute toxicities W8–W12 | Response | mSWAT reduction | PFS (W) | FU |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | M/69 | SS | 2 × 4 Gy | None | Bexarotene | Edema, erythema, and nail atrophy grade 2 | Edema and alopecia grade 1 | PR | 88% at W8 | 26 | Alive without evidence of progression |
2 | M/66 | MF/IIB | 2 × 4 Gy | None | Mogamulizumab | Sepsis, alopecia grade 1, and nausea grade 1 | Nail changes and alopecia grade 1 | PR | 87% at W8 | 26 | Died due to COVID-19 |
3 | M/78 | MF/IIB | 2 × 4 Gy | Bexarotene | Bexarotene | Edema, erythema grade, alopecia, and blistering grade 1 | Alopecia grade 1 | PR | 73% at W8 | 26 | Alive without evidence of progression |
4 | F/77 | SS | 2 × 4 Gy | None | Bexarotene, ECP | Erythema grade 2, edema grade 2, alopecia grade 1 | Fatigue, nail changes, and alopecia grade 1 | PR | 63% at W8 | 22 | Alive without evidence of progression |
5 | M/60 | MF/IIB | 2 × 4 Gy | Bexarotene | Bexarotene | Erythema and fatigue grade 1 | Fatigue, and edema grade 1 | PR | 89% at W8 | 19 | Alive without evidence of progression |
6 | F/55 | MF/IIB | 2 × 4 Gy | Acitretin | Acitretin | Fatigue, erythema, and blistering grade 1 | None | CR | 100% at W4 | 18 | Alive without evidence of disease |
ECP extracorporeal photopheresis, CR complete response, W week, PR partial remission, PFS progression-free survival, FU follow-up, M male, F female, MF mycosis fungoides, SS Sézary syndrome