Fig. 1.

Proposed immunological mechanism possibly triggered by antibody production in MIS-C. In genetically susceptible individuals, SARS-CoV-2 infections causes viral specific antibodies and there might be cross-reactive antibodies binding to host antigens. These antibodies may bind to Fcγ receptors in neutrophils and macrophages causing activation and secretion of pro-inflammatory cytokines that results in development of MIS-C. IFITM3 interferon-induced transmembrane protein-3, CD40LG cluster of differentiation 40 (CD40) ligand, HLA-B15:03 human leukocyte antigen (HLA) B15:03, ACE1 angiotensin-converting enzyme 1