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. 2020 Nov 17;14:4993–5004. doi: 10.2147/DDDT.S259547

Table 4.

Cytotoxic Activity (IC50) of Glycosylated Derivatives of Squamocin and Bullatacin

Compound IC50 (µM)
A549 HeLa HepG2
Squamocin (1) 1.99 ± 0.49 0.93 ± 0.079 1.70 ± 0.14
4 6.62 ± 1.23 1.96 ± 0.23 2.93 ± 0.44
5 4.60 ± 0.69 2.24 ± 0.049 2.82 ± 0.31
11 3.88 ± 0.005 7.16 ± 1.45 1.52 ± 0.40
12 4.67 ± 0.69 3.24 ± 0.57 1.97 ± 0.18
13 2.99 ± 0.39 0.98 ± 0.13 4.09 ± 0.68
14 6.33 ± 0.96 1.56 ± 0.16 1.68 ± 0.29
15 1.80 ± 0.25 0.77± 0.0092 0.98 ± 0.042
Bullatacin (2) 1.74 ± 0.34 1.42 ± 0.14 2.48 ± 0.29
17 1.46 ± 0.38 13.77 ± 1.51 1.51 ± 0.09
18 15.44 ± 2.93 1.42 ± 0.12 1.13 ± 0.17