Table 4.
Cytotoxic Activity (IC50) of Glycosylated Derivatives of Squamocin and Bullatacin
Compound | IC50 (µM) | ||
---|---|---|---|
A549 | HeLa | HepG2 | |
Squamocin (1) | 1.99 ± 0.49 | 0.93 ± 0.079 | 1.70 ± 0.14 |
4 | 6.62 ± 1.23 | 1.96 ± 0.23 | 2.93 ± 0.44 |
5 | 4.60 ± 0.69 | 2.24 ± 0.049 | 2.82 ± 0.31 |
11 | 3.88 ± 0.005 | 7.16 ± 1.45 | 1.52 ± 0.40 |
12 | 4.67 ± 0.69 | 3.24 ± 0.57 | 1.97 ± 0.18 |
13 | 2.99 ± 0.39 | 0.98 ± 0.13 | 4.09 ± 0.68 |
14 | 6.33 ± 0.96 | 1.56 ± 0.16 | 1.68 ± 0.29 |
15 | 1.80 ± 0.25 | 0.77± 0.0092 | 0.98 ± 0.042 |
Bullatacin (2) | 1.74 ± 0.34 | 1.42 ± 0.14 | 2.48 ± 0.29 |
17 | 1.46 ± 0.38 | 13.77 ± 1.51 | 1.51 ± 0.09 |
18 | 15.44 ± 2.93 | 1.42 ± 0.12 | 1.13 ± 0.17 |