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. 2020 Nov 20;10:20314. doi: 10.1038/s41598-020-76973-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Simplified cholesterol metabolic pathway. Cholesterol can be synthesised via either the Kandutsch–Russell Pathway (on left) or the Bloch Pathway (on right). Symbols next to each metabolite indicate whether it has been identified as either increased (up arrow), decreased (down arrow) or unchanged (dash) in the putamen (blue) and caudate (red) human post-mortem tissue (Kreilaus et al. 2016). ACAT 1 acyl-coenzyme cholesterol acyltransferase, CE cholesteryl ester.