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. 2020 Nov 20;7:40. doi: 10.1038/s41439-020-00127-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The steps involved in computing palindromes in personal genomes, identifying and cataloging palindromic variations with respect to the reference genome, and applications of the methodology are shown in the schematic diagram. Further, the specific methods that were followed to b align palindromes in the personal genomes to those in the reference genome and c catalog palindromic changes across individuals are shown. *The newly inserted nucleotide creates a gap between the complementary halves and fails to create a palindrome that fits our definition.