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. 2020 Nov 17;15:9011–9023. doi: 10.2147/IJN.S271519

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© 2020 Xu et al.

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DiR-labeled MSC-exos homed to ischemic foci after stroke. (A) NIRFI of DiR-labeled MSC-exos after ultracentrifugation from free DiR solution. (B) Linear correlation between the fluorescence signal intensity and MSC-exo concentration. (C) The average radiant efficiency based on NIRF images on days 1 and 3 in the DiR-labeled MSC-exo-treated group was significantly increased compared with that in the unlabeled MSC-exo-treated group (n=6-8/group; ****p<0.0001). (D) Representative NIRF images of ischemic stroke brains from the DiR-labeled group MSC-exo-treated and unlabeled MSC-exo-treated group. (E) Above: representative ex vivo NIRF images of brains from the DiR-labeled MSC-exo-treated group and unlabeled MSC-exo-treated group on day 3. Below: Quantification of the average radiant efficiency based on NIRF images of ex vivo brains on day 3 in the two groups (n=3-4/group; *p<0.05). (F) The average radiant efficiency based on NIRF images of isolated organs from the DiR-labeled MSC-exo-treated group on day 3. (G) Representative NIRF image of tissues from the DiR-labeled MSC-exo-treated group on days 3 and 14. (H) Representative immunofluorescence images of neurons in the peri-infarct area in the DiR-labeled MSC-exo-treated group on day 3, ×400.