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. 2020 Nov 16;14:4915–4949. doi: 10.2147/DDDT.S274980

Table 3.

Bioactive Components of Natural Medicine That Can Promote HIF-1α

Compounds Original Plants Chemical Structure Models Mechanism Disease Refs.
Glycosides
Astragaloside IV Astragalus propinquus Schischkin graphic file with name DDDT_A_274980_O_ILF0043.jpg HUVECs Promoting cell proliferation and stimulated HIF-1α accumulation by PI3K/Akt pathway, not affecting the degradation of HIF-1α protein or the level of HIF-1α mRNA, inducing the nuclear translocation of HIF-1α. Myocardial ischemia [171]
Notoginsenoside R1 Panax notoginseng (Burk.) F.H.Chen graphic file with name DDDT_A_274980_O_ILF0044.jpg Male SD rats (200 ± 20 g) with cisplatin Reducing the levels of ROS, MDA and NO, as well as the opening of MPTP, increasing the levels of HIF-1α mRNA, SOD, CAT and GSH, as well as ATP and MMP in renal tissues. Mitochondrial damage induced by cisplatin [172]
Salidroside Rhodiola rosea L. graphic file with name DDDT_A_274980_O_ILF0045.jpg Neonatal rat cardiomyocyte Up-regulating the HIF-1α and VEGF protein expression, inducing HIF-1α translocation; Heart failure [173]
HEK293T, HepG2 cells Inducing the expression of EPO mRNA from its transcription regulatory HRE, stimulating the accumulation of HIF-1α by inhibiting HIF-1α degradation Mountain sickness [89,117]
ROB, MG-63 cells Stimulating osteoblast differentiation and mineralization by inducing the expression of Runx2 and Osterix, up-regulating HIF-1α expression at the
mRNA and protein levels via MAPK/ERK and PI3K/Akt signaling.		 Fracture [118]
Polysaccharides
Rhamnose, xylose, mannose, galactose, glucose Enteromorpha Prolifera Inline graphicInline graphicInline graphicInline graphic HCMVEC; Protecting HCMVEC from OGD-induced viability loss, proliferation inhibition, apoptosis, inflammatory cytokine expression, and autophagy, enhancing the expression of HIF-1α in HCMVEC via the MEK/ERK pathway, attenuating OGD-induced NF-κB pathway activation and promoted the mTOR pathway in HCMVEC; Acute myocardial infarction [174]
Wistar rats pre-treated by PEP Reducing the infarct size and enhancing the LVEDD, LVEF and LVFS of rats via up-regulation of HIF-1α. Acute myocardial infarction [174]
Quinones
Tanshinone IIA Salvia miltiorrhiza Bge. graphic file with name DDDT_A_274980_O_ILF0050.jpg Male SD rats weighing 200- Improving heart function, reducing infarct size, and increasing survival rate, up-regulating the expression of HIF-1α and VEGF. Myocardial ischemia [120]
220 g (aged 10 weeks) with myocardial infarction Improving heart function, reducing infarct size, and increasing survival rate, up-regulating the expression of HIF-1α and VEGF. Myocardial ischemia [120]