Table 8.

Association of PSRC1, CELSR2, and SORT1 SNPs with Variability on Warfarin Required Doses

Gene	SNP ID	Genotype	Initiation Dose	Overall P-value*	Maintenance Dose	Overall P-value*
PSRC1	rs646776	CC	66.92 [78.79]	<0.0001	48.55 [29.53]	0.107
		CT	33.74 [16.20]		34.85 [17.20]
		TT	37.67 [13.19]		39.95 [17.03]
CELSR2	rs660240	CC	38.03 [14.42]	<0.0001	41.00 [18.32]	0.036
		TC	33.07 [13.30]		33.78 [14.43]
		TT	66.92 [78.79]		48.55 [29.53]
	rs12740374	GG	38.17 [14.25]	<0.0001	40.48 [17.89]	0.031
		GT	32.22 [13.15]		33.67 [14.63]
		TT	75.59 [85.41]		51.26 [32.17]
SORT1	rs602633	GG	37.06 [13.05]	0.002	40.02 [17.23]	0.33
		GT	35.57 [16.70]		35.69 [17.31]
		TT	57.79 [68.63]		42.37 [26.07]

Notes: *One-way ANOVA test with p< 0.05 is considered significant, Mean Standard deviation in square brackets.