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. 2020 Nov 17;13:11781–11794. doi: 10.2147/OTT.S262049

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© 2020 Wang et al.

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Construction of stable MCU knockdown or overexpression gastric cancer cells. (A) Representative immunofluorescence images of stable MCU knockdown SNU-1 and HGC-27 cells. (B, C) Western blot analysis results showed that MCU was successfully silenced in SNU-1 and HGC-27 cells transfected with MCU siRNAs. (D, E) CCK-8 assay detected the cell viability of SNU-1 and HGC-27 cells treated with different concentrations of MCU agonist Spermine. (F) Flow cytometry results showing the effects of different concentrations of MCU agonist Spermine on gastric cancer cell apoptosis. (G, H) Immunofluorescence assay results showing the expression levels of MCU in SNU-1 and HGC-27 cells transfected with MCU siRNAs or Spermine. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.