Fig. 3.

Systemic immune responses elicited by the pAc/emm55 vector in B16-bearing mice are T cell dependent. C57BL/6 mice were injected with a 3 weekly doses of pAc/Empty or pAc/emm55 plasmid IL. CGGC permutation test p = 0.02. Mice were pretreated with b anti-CD4 or c anti-CD8 antibody (300 μg/200μL/intraperitoneal) starting on day 3 and continuing twice a week until the endpoint. Control mice received isotype control. CD4 or CD8 T cells abrogate the activity of the emm55 vector. The p values utilizing the Student’s t test are presented for the last two time points on the growth curve. d Combined graph with all controls represented. N = 6 per group