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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Gastroenterology. 2020 Jul 24;159(5):1866–1881.e8. doi: 10.1053/j.gastro.2020.07.037

Figure 6. Tuft cell and Hpgds expression in human pancreatic tumorigenesis.

Figure 6.

(A) Heat map with hierarchical clustering showing a significant decrease in tuft cell-associated genes between pre-invasive PanIN and IPMN (n = 45) and PDA (n = 197), as well as between classical and basal-like PDA (p<0.01). ssGSEA, single sample gene set enrichment analysis. (B) RNA-seq of Hpgds in matched epithelial and stromal compartments from the same patients. Whiskers, minimum to maximum values (C) Co-immunofluorescence for tuft cell marker phospho-EGFR, red, and Hpgds, green, in human pancreatitis. Scale bar, 20μm.