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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Cancer Metastasis Rev. 2020 Sep 7;39(4):1179–1203. doi: 10.1007/s10555-020-09925-3

Figure 1: Diverse Cellular Activation Processes of Autophagy.

Figure 1:

Autophagy occurs in mTOR dependent and mTOR independent manners as well as through activation of ROS species. Gastric cancer has been found to have autophagy activation in all of these manners. Targeting autophagy is being investigated both with mTOR inhibition, hypoxic gene inhibition or deacetylation inducing compounds (See Table 2).