Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 Oct 3;44(11):2316–2325. doi: 10.1111/acer.14461

Figure 4. Effect of NBQX on Continuous Alcohol Consumption and Locomotor Activity in Selectively Bred HAP3 mice.

Figure 4.

Male and female HAP3 mice were treated with one of four doses of NBQX (n=9/dose/sex) and alcohol consumption and locomotor activity was monitored during two, four, and 24 hours into a 24-hour two-bottle choice drinking session on day 20 of DID. A. Neither sex nor NBQX altered alcohol drinking during hours 1-2 (p’s > 0.05). B. Main effect of sex on alcohol drinking during hours 3-4 (****p < 0.0001). C. 24-hours later, female mice consumed significantly more than male mice at 10 mg/kg (*p < 0.05). D. Main effect of sex on locomotor activity at hours 1-2 (****p < 0.0001). E. Main effect of sex on locomotor activity at hours 3-4 (***p < 0.001). F. Female mice had significantly more locomotor activity than male mice 24-hours later (***p < 0.001).