Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Metabolism. 2020 Oct 10;113:154392. doi: 10.1016/j.metabol.2020.154392

Figure 5: Mechanism of restoration of reproductive function in women with hypothalamic amenorrhea by leptin.

Figure 5:

Women with hypothalamic amenorrhea that respond to leptin treatment and have their reproductive function restored show a distinct hormonal profile when compared to non-responders. This hormonal profile is characterized by higher LH/FSH ratio, apparently due to the central effects of leptin on GnRH secretion in hypothalamus. Responders also have higher peaks of E2 and Inhibin A in blood, which indicates improved ovarian function and restoration of normal regular menstrual cycles. Additionally, circulating AMH, which serves as an additional marker of ovarian recovery, is reduced.

AMH: Anti-mullerian hormone; E2: Estradiol; FSH: Follicle-stimulating hormone; GnRH: Gonadotropin-releasing hormone; LH: Luteinizing hormone