Table 1:
Clinical spectrum of disease in HIF1A−/−EKPC mice
Clinical spectrum of disease in EKPC mice
| No. | ID | Genotype | Gender | DOB | DOD | Age (days) | PDA | Liver | Lung | Dia | Lymph | Others | Organs involved in invasion | Total Organ met burden |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ES33 | EKPC Hif1α fl/fl | F | 11/16/13 | 04/03/14 | 138 | Y (+++) | Ym | N | N | Y | Dd; Ld, Adherent to K | 2 | 1 |
| 2 | ES110 | EKPC Hif1α fl/fl | F | 01/08/14 | 05/29/14 | 141 | Y(+) | N | N | N | N | 0 | 0 | |
| 3 | ES388 | EKPCHif1α fl/fl | M | 07/14/14 | 10/24/14 | 102 | Y(++) | N | N | YM | Y | Ld; Adherent to Sp | 1 | 1 |
| 4 | ES469 | EKPC Hif1α fl/fl | M | 09/13/14 | 11/18/14 | 66 | Y(+++) | Ym | N | N | Y | Lpd | 1 | 1 |
| 5 | ES593 | EKPC Hif1α fl/fl | M | 12/14/14 | 03/15/15 | 91 | Y(+++) | Ym | N | YM | Y | Dd; Ld | 3 | 2 |
| 6 | ES596 | EKPC Hif1α fl/fl | M | 12/14/14 | 04/28/15 | 135 | Y(+) | N | Ym | N | Y | Id | 1 | 1 |
| 7 | ABA614 | EKPCHif1α fl/fl | F | 01/16/13 | 08/05/13 | 199 | Y(+++) | YM | YM | YM | Y | Dd; Std; Id | 3 | 3 |
| 8 | ES643 | EKPC Hif1α fl/fl | M | 01/06/15 | 05/15/15 | 129 | Y(+++) | Ym | Ym | Ym | N | 0 | 3 | |
| 9 | ABA618 | EKPC Hif1α fl/fl | M | 01/16/13 | 05/19/13 | 123 | Y(+++) | Ym | N | YM | Y | Dd; Kd; GBd | 3 | 2 |
| 10 | ES658 | EKPCHif1α fl/fl | F | 01/24/15 | 05/22/15 | 118 | Y(+) | N | Ym | N | Y | Spm; GBM | 1 | 3 |
| 11 | ABA664 | EKPC Hif1α fl/fl | M | 02/16/13 | 07/25/13 | 159 | Y (+++) | YM | N | N | Y | 0 | 1 | |
| 12 | ES696 | EKPC Hif1α fl/fl | F | 02/14/15 | 07/24/15 | 160 | Y(++) | Ym | YM | N | N | Stm | 0 | 3 |
| 13 | ES717 | EKPC Hif1α fl/fl | M | 03/03/15 | 05/22/15 | 80 | Y(++) | Ym | YM | Ym | N | Dd; Id | 2 | 3 |
| 14 | ABA742 | EKPCHif1α fl/fl | F | 03/17/13 | 07/09/13 | 114 | Y(+++) | Ym | N | N | Y | Dd; Std; Adherent to I | 2 | 1 |
| 15 | ABA763 | EKPC Hif1α fl/fl | F | 03/06/13 | 07/25/13 | 141 | Y(+++) | Ym | YM | Ym | Y | Dd; Ld; LpM | 2 | 4 |
| 16 | ABA784 | EKPC Hif1α fl/fl | M | 03/25/13 | 07/04/13 | 99 | Y(++) | Ym | Ym | N | Y | Dd; Ld | 2 | 1 |
| 17 | ABA 869 | EKPCHif1α fl/fl | M | 04/24/13 | 08/15/13 | 113 | Y (+++) | YM | N | N | Y | Id; Ld | 2 | 1 |
| 18 | ABA909 | EKPC Hif1α fl/fl | M | 05/06/13 | 09/10/13 | 127 | Y(+++) | YM | N | N | Y | Dd; Ld | 2 | 1 |
| 19 | ABA933 | EKPC Hif1α fl/fl | M | 05/18/13 | 08/26/13 | 100 | Y(+++) | Ym | N | YM | Y | Dd; Ld | 2 | 2 |
| 20 | ABA950 | EKPC Hif1α fl/fl | M | 05/24/13 | 08/15/13 | 83 | Y(+++) | YM | YM | YM | Y | Spm, Km, Hm, Diad, Ld, Dd,LgD | 4 | 5 |
| 21 | ABA954 | EKPCHif1α fl/fl | M | 05/30/13 | 09/13/13 | 106 | Y(+++) | N | N | N | Y | Dd | 1 | 0 |
| 22 | ABA973 | EKPC Hif1α fl/fl | M | 07/01/13 | 10/17/13 | 108 | Y(+) | Ym | Ym | N | Y | 0 | 3 | |
| 23 | ABA1029 | EKPC Hif1α fl/fl | F | 08/28/13 | 12/02/13 | 94 | Y(+) | N | Ym | N | Y | Ld | 1 | 1 |
| 24 | ABA1031 | EKPCHif1α fl/fl | M | 08/28/13 | 10/08/13 | 41 | Y(+++) | N | YM | N | Y | Std | 1 | 1 |
| No. | ID | Genotype | Gender | DOB | DOD | Age (days) | PDA | Liver | Lung | Dia | Lymph | Others | Organs involved in invasion | Total Organ met burden |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ES149 | EKPC | F | 02/05/14 | 07/30/14 | 175 | Y(+++) | YM | YM | YM | Y | Dd; Ld; Spd | 3 | 3 |
| 2 | ES154 | EKPC | M | 02/05/14 | 10/29/14 | 177 | Y(++) | N | N | N | Y | 0 | 0 | |
| 3 | ES236 | EKPC | M | 03/24/14 | 05/29/14 | 66 | Y(+) | Ym | N | N | N | 0 | 1 | |
| 4 | ES273 | EKPC | M | 04/19/14 | 10/14/14 | 175 | Y(++) | N | N | N | N | 0 | 0 | |
| 5 | ES368 | EKPC | M | 07/05/14 | 02/08/15 | 213 | Y(++) | N | N | N | Y | Dd | 1 | 0 |
| 6 | ABA336 | EKPC | M | 08/16/12 | 12/12/12 | 116 | Y(+++) | N | N | N | N | 0 | 0 | |
| 7 | ABA405 | EKPC | F | 10/15/12 | 05/13/13 | 210 | Y(+) | Ym | N | YM | Y | 0 | 2 | |
| 8 | ABA407 | EKPC | F | 10/15/12 | 04/08/13 | 175 | Y(+) | YM | N | N | N | 0 | 1 | |
| 9 | ABA541 | EKPC | F | 12/10/12 | 03/17/13 | 97 | Y(+) | N | N | N | N | 0 | 0 | |
| 10 | ABA567 | EKPC | F | 12/27/12 | 09/06/13 | 249 | Y(++) | YM | N | N | Y | 0 | 1 | |
| 11 | ABA571 | EKPC | M | 12/27/12 | 07/25/13 | 208 | Y(++) | N | YM | N | N | 0 | 1 | |
| 12 | ABA642 | EKPC | F | 02/11/13 | 05/01/13 | 79 | Y(+++) | Ym | N | N | N | Id | 1 | 1 |
| 13 | ABA775 | EKPC | M | 03/24/13 | 08/06/13 | 135 | Y(+) | YM | N | N | Y | 0 | 1 | |
| 14 | ABA806 | EKPC | F | 04/06/13 | 07/12/13 | 97 | Y(++) | Ym | N | N | Y | 1 | 1 | |
| 15 | PP451 | KPC | M | 01/10/14 | 08/20/14 | 222 | Y(+++) | N | Ym | N | N | 0 | 1 | |
| 16 | PP509 | KPC | M | 02/01/14 | 09/30/14 | 241 | Y(+++) | N | N | N | Y | 0 | 0 | |
| 17 | PP793 | KPC | M | 04/19/14 | 08/28/14 | 131 | Y(+++) | N | Ym | N | N | Ld | 1 | 1 |
| 18 | PP866 | KPC | M | 05/16/14 | 10/22/14 | 159 | Y(++) | Ym | Ym | N | N | Ld | 1 | 2 |
| 19 | PP901 | KPC | F | 05/24/14 | 09/18/14 | 117 | Y (+++) | N | N | N | Y | 0 | 0 | |
| 20 | PP1011 | KPC | F | 06/19/14 | 12/19/14 | 183 | Y (+++) | N | Ym | N | Y | 0 | 2 | |
| 21 | PP1012 | KPC | F | 06/19/14 | 10/03/14 | 106 | Y(+) | N | N | N | N | 0 | 0 | |
| 22 | PP1034 | KPC | M | 06/21/14 | 12/21/14 | 183 | Y(+++) | YM | Ym | Ym | Y | 0 | 3 | |
| 23 | PP1041 | KPC | M | 06/27/14 | 09/10/14 | 75 | Y(+) | N | N | N | N | 0 | 0 | |
| 24 | PP1051 | KPC | F | 06/30/14 | 10/03/14 | 95 | Y(++) | N | N | N | N | 0 | 0 | |
| 25 | PP1091 | KPC | F | 08/13/14 | 11/13/14 | 90 | Y(+++) | N | N | Ym | N | 0 | 1 |
Y, disease detected [ >50% normal acini (+); 20–50% normal acini (++) and <20 % normal acini (+++)]; N, no disease detected; M, macrometastasis; m, micrometastasis; d, direct invasion; Ab, abdominal wall; L, liver; Lp, lymph node, I, intestine; Sp, spleen; St, stomach; GB, gall bladder; K, kidney; D, Duodenum