Table 2.
Effect of NU7441 on cortical and trabecular bone parameters
| DMSO (n=10) | NU7441 (n=7) | |
|---|---|---|
| Cortical thickness (mm) | 0.18 ± 0.002 | 0.18 ± 0.002 |
| Cortical BV/TV (%) | 93.95 ± 0.06 | 93.97 ± 0.06 |
| Cross-sectional area (mm2) | 0.87 ± 0.015 | 0.88 ± 0.015 |
| Medullary area (mm2) | 0.05 ± 0.001 | 0.05 ± 0.0005 |
| Trabecular BV/TV (%) | 3.07 ± 0.19 | 3.25 ± 0.24 |
| Trabecular thickness (mm) | 0.04 ± 0.001 | 0.04 ± 0.001 |
| Trabecular separation (mm) | 0.35 ± 0.01 | 0.36 ± 0.01 |
| Trabecular number (mm−1) | 0.81 ± 0.04 | 0.82 ± 0.07 |
Nineteen-week old female mice were treated once daily with 10 mg/kg of NU7441 for 21 days.