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. Author manuscript; available in PMC: 2021 Nov 19.
Published in final edited form as: Cell Chem Biol. 2020 Jul 28;27(11):1347–1358.e5. doi: 10.1016/j.chembiol.2020.07.007

Figure 2 |. ENPP1 inhibitors with a zinc-binding phosphonate head group exhibit high potency at physiological pH.

Figure 2 |

(A) Chemical structure of the R group (core = piperidine, tail = 6,7-dimethoxy quinazoline). (B) Chemical structures of zinc-binding heads with corresponding Ki values (mean of at least 2 independent replicates) at pH 7.4 and pH 9.0. Ki values were determined using 3 nM ENPP1 and 5 μM cGAMP.