Skip to main content
. Author manuscript; available in PMC: 2021 Nov 19.
Published in final edited form as: Cell Chem Biol. 2020 Jul 28;27(11):1347–1358.e5. doi: 10.1016/j.chembiol.2020.07.007

Figure 4 |. Piperidine and benzyl amine cores are optimal molecular linkers.

Figure 4 |

(A) Chemical structures of the R1 group (phosphonate head) and the R2 group (6,7-dimethoxy quinazoline tail). (B) Chemical structures of cores with corresponding Ki values (mean of at least 2 independent replicates) at pH 7.4. Ki values were determined using 3 nM ENPP1 and 5 μM cGAMP.