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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Pharm Sci. 2020 Sep 8;109(12):3598–3607. doi: 10.1016/j.xphs.2020.09.007

Figure 4:

Figure 4:

Schematic of development of design space from sweet spot contours and actual variation in the monitored attributes during a continuous process of the optimized formulation