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. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: J Pharm Sci. 2020 Sep 8;109(12):3598–3607. doi: 10.1016/j.xphs.2020.09.007

Table 2.

Summary of PLS regression results for encoded independent variables

Variable	Drug release (%)
	120 min in pH 1.2		30 min in pH 6.8		45 min in pH 6.8
	Coeff.	P	Coeff.	P	Coeff.	P
Constant	6.75	0.000	83.04	0.000	93.05	0.000
Drug load	0.72	0.024	3.50	0.013	1.73	0.009
SA content	−2.35	0.000	−2.10	0.064	−0.22	0.579
Pellet size	−2.65	0.000	−6.97	0.001	−4.77	0.000
(Drug load)*(SA content)	0.12	0.529	−0.97	0.259	−1.10	0.027
(Drug load)*(Pellet size)	−0.32	0.154	0.82	0.327	0.00	0.995
(SA content)* (Pellet size)	−0.19	0.356	1.17	0.189	−0.25	0.473
Goodness of prediction (Q²)	0.672		0.511		0.737
Goodness of fit (R²)	0.988		0.962		0.982
P-Model Correctness	0.001		0.008		0.002