Fig. 4.

Time-course changes in the administration dosages of drugs for the treatment of complications. a Changes in administration doses of diuretics for hepatic edema. The proportion of patients who received the same, increased the doses or initiated diuretics significantly decreased after achieving sustained virologic response at 12-week post-treatment (SVR12) (p = 1.46 × 10⁻² by the Cochran–Armitage trend test). b Changes in administration of branched chain amino acid (BCAA) for hepatic encephalopathy and/or hypoalbuminemia. The proportion of patients who continued to receive BCAA treatment was significantly reduced from baseline to 12-week post-treatment among patients who achieved SVR12 (p = 2.44 × 10⁻² by the Cochrane–Armitage trend test)