Fig. 6.

IPA analysis revealed that ivermectin was associated with production of ROS and energy metabolism. a Disease and function analysis of ivermectin based on IPA software. b Biomolecular networks analysis of ivermectin based on IPA software showed that ivermectin regulated PKM. c Biomolecular networks analysis of ivermectin based on IPA software showed that ivermectin regulated OGDHL. d Biomolecular networks analysis of ivermectin based on IPA software showed that ivermectin regulated ND2. e Biomolecular networks analysis of ivermectin based on IPA software showed that ivermectin regulated ND5. f Biomolecular networks analysis of ivermectin based on IPA software showed that ivermectin regulated UQCRH. IPA, Ingenuity Pathway Analysis; ROS, reactive oxygen species; PKM, pyruvate kinase muscle; OGDHL, oxoglutarate dehydrogenase L; ND2, mitochondrially encoded NADH dehydrogenase 2; ND5, mitochondrially encoded NADH dehydrogenase 5; UQCRH, ubiquinol-cytochrome c reductase hinge protein