Table 4.

Kreb’s cycle involved mtDEPs operated in ovarian cancer biological system

Pathway code	Accession no.	Protein	Unique peptides	Coverage (%)	PSMs	Calc. pI	MW (kDa)	Ratio (T/N)	p value (t test)
4.2.1.3	P21399	Aconitase 1 (ACO1)	10	13.27	13	6.7	98.34	0.65	6.04E-03
4.1.1.32	Q16822	PCK2 protein (PCK2)	1	35.00	31	7.6	70.68	2.18	4.48E-03
1.2.4.1	P11177	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB)	14	52.92	79	6.7	39.21	1.51	3.25E-03
1.1.1.37	Q75MT9	Malate dehydrogenase (fragment) (MDH2)	21	74.37	262	8.3	33.21	1.71	5.51E-03
2.3.3.1	B4DJV2	Citrate synthase (CS)	13	26.93	73	7.9	50.40	1.59	4.65E-03
1.1.1.42	P48735	Isocitrate deh1ydrogenase (NADP), mitochondrial (IDH2)	27	56.64	355	8.7	50.88	2.02	2.07E-03
1.1.1.41	O43837	Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial (IDH3B)	13	41.56	43	8.5	42.16	1.75	8.69E-03
1.1.1.41	P50213	Isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial (IDH3A)	18	47.81	53	6.9	39.57	1.60	2.27E-02
4.2.1.2	P07954	Fumarate hydratase, mitochondrial (FH)	7	35.69	137	8.8	54.60	1.61	8.84E-03
6.2.1.4	Q96I99	Succinate–CoA ligase (GDP-forming) subunit beta, mitochondrial (SUCLG2)	19	44.91	115	6.4	46.48	1.71	8.17E-04
1.2.4.2	Q9ULD0	2-Oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)	13	26.83	58	6.7	114.41	1.55	1.25E-03

Ratio (T/N) means the ratio of tumor to control

mtDEPs, mitochondrial differentially expressed proteins; pI, isoelectric point; MW, molecular weight; PSMs, peptide spectrum matches