Table 5.
Oxidative phosphorylation involved mtDEPs operated in ovarian cancer biological system
| Pathway code | Accession no. | Protein | Unique peptides | Coverage (%) | PSMs | Calc. pI | MW (kDa) | Ratio (T/N) | p value (t test) |
|---|---|---|---|---|---|---|---|---|---|
| 1.6.5.3 | A0A059T3A1 | NADH-ubiquinone oxidoreductase chain 2 (ND2) | 1 | 4.61 | 2 | 9.8 | 38.93 | 0.38 | 6.03E-04 |
| 1.6.5.3 | A0A096WB60 | NADH-ubiquinone oxidoreductase chain 5 (ND5) | 1 | 5.14 | 6 | 9.0 | 67.01 | 0.38 | 3.34E-04 |
| 1.10.2.2 | A0A0A0QN99 | Cytochrome b (cytb) | 1 | 4.21 | 4 | 8.0 | 42.71 | 1.71 | 7.60E-03 |
| 1.10.2.2 | P07919 | Cytochrome b-c1 complex subunit 6, mitochondrial (QCR6) | 5 | 51.65 | 18 | 4.4 | 10.73 | 1.59 | 1.63E-02 |
| 1.9.3.1 | H7C4E5 | COX17, cytochrome c oxidase copper chaperone (COX17) | 1 | 12.07 | 1 | 7.7 | 6.41 | 2.75 | 2.33E-03 |
| 1.9.3.1 | H9LP39 | Cytochrome c oxidase subunit I (COX1) | 1 | 6.04 | 1 | 6.7 | 57.01 | 1.79 | 2.44E-03 |
| 1.9.3.1 | P09669 | Cytochrome c oxidase subunit 6C (COX6C) | 7 | 52 | 30 | 10.4 | 8.78 | 1.54 | 5.97E-03 |
| 1.9.3.1 | Q96KJ9 | Cytochrome c oxidase subunit 4I2 (COX4I2) | 1 | 5.85 | 1 | 9.6 | 20.00 | 0.21 | 6.28E-04 |
| 1.9.3.1 | P13073 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) | 7 | 36.09 | 48 | 9.5 | 19.56 | 1.52 | 4.37E-03 |
| 1.9.3.1 | A0A097Q0T5 | Cytochrome c oxidase subunit 2 (COX2) | 1 | 26.43 | 64 | 4.8 | 25.55 | 1.68 | 4.38E-02 |
| 1.9.3.1 | H9E7B8 | Cytochrome c oxidase subunit 2 (fragment) (COX2) | 1 | 27.27 | 65 | 4.7 | 24.84 | 1.88 | 1.97E-02 |
| 1.9.3.1 | O14548 | Cytochrome c oxidase subunit 7A2 like (COX7A2L) | 4 | 54.39 | 8 | 9.4 | 12.61 | 1.88 | 5.33E-03 |
| 1.9.3.1 | P14406 | Cytochrome c oxidase subunit 7A2 (COX7A2) | 2 | 27.71 | 15 | 9.8 | 9.39 | 1.55 | 3.89E-02 |
| 3.6.3.1.4 | P27449 | ATPase H+ transporting V0 subunit c (ATP6V0C) | 1 | 11.61 | 18 | 8.4 | 15.73 | 1.63 | 4.24E-04 |
| 3.6.3.1.4 | A0A059QB80 | ATP synthase subunit a (ATP6) | 1 | 4.42 | 17 | 10.1 | 24.74 | 1.79 | 6.63E-03 |
| 3.6.3.1.4 | G3V2V6 | ATPase H+ transporting V1 subunit D (ATP6V1D) | 1 | 7.43 | 1 | 9.5 | 17.41 | 1.54 | 8.22E-04 |
| 3.6.3.1.4 | I3L0Y5 | ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) (ATP5G1) | 1 | 7.14 | 6 | 10.0 | 10.03 | 1.58 | 9.78E-03 |
Ratio (T/N) means the ratio of tumor to control
mtDEPs, mitochondrial differentially expressed proteins; pI, isoelectric point; MW, molecular weight; PSMs, peptide spectrum matches