Table 6.
SILAC-based quantitative proteomics analysis of the protein expressions of energy metabolic pathways in ovarian cancer cells TOV-21G treated with (SILAC: H) and without (SILAC: L) 20 μM ivermectin for 24 h, and verified with qPCR and western blot
| Pathway | Protein ID | Gene name | Protein name | Peptides | Unique peptides | Sequence coverage [%] | Mol. weight [kDa] | Sequence length | Score | Q value | Intensity H | Intensity L | Ratio H/L |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glycolysis pathway | PFKAP | PFKP | ATP-dependent 6-phosphofructokinase, platelet type | 31 | 28 | 46.7 | 85.6 | 784 | 323.3 | 0.00E+00 | 14,226,000,000 | 25,587,000,000 | 0.54 |
| H3BQ34 | PKM | Pyruvate kinase | 1 | 1 | 0.0 | 30.7 | 281 | 1.9 | 7.46E-03 | 10,727,000 | 0 | + | |
| ODPB | PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 9 | 9 | 34.0 | 39.2 | 359 | 67.1 | 0.00E+00 | 407,280,000 | 1,649,500,000 | 0.46 | |
| K4EN11 | GAPDH | GAPDH (fragment) | 1 | 1 | 48.1 | 2.8 | 27 | 6.3 | 0.00E+00 | 0 | 0 | / | |
| ENOA | ENO1 | Alpha-enolase | 21 | 11 | 65.9 | 47.2 | 434 | 323.3 | 0.00E+00 | 54,687,000,000 | 125,660,000,000 | 0.44 | |
| F5GXY2 | LDHA | L-lactate dehydrogenase A chain (fragment) | 15 | 1 | 82.1 | 17.3 | 156 | − 2.0 | 1.00E+00 | 10,379,000 | 29,470,000 | 0.34 | |
| Q5U077 | LDHB | L-lactate dehydrogenase | 17 | 8 | 49.4 | 36.6 | 334 | 160.4 | 0.00E+00 | 27,852,000,000 | 66,990,000,000 | 0.42 | |
| A0A0A0MTS2 | GPI | Glucose-6-phosphate isomerase (fragment) | 21 | 1 | 48.0 | 64.8 | 573 | − 2.0 | 1.00E+00 | 56,685,000 | 138,520,000 | 0.44 | |
| Q6IRT1 | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase | 16 | 16 | 52.9 | 39.7 | 374 | 115.0 | 0.00E+00 | 1,308,100,000 | 3,513,700,000 | 0.45 | |
| B3KUV2 | ACSS2 | cDNA FLJ40707 fis, clone THYMU2026835, highly similar to acetyl-coenzyme A synthetase, cytoplasmic | 2 | 2 | 6.6 | 45.5 | 409 | 1.8 | 9.53E-03 | 9,455,200 | 25,758,000 | 0.73 | |
| H3BRS6 | ADPGK | ADP-dependent glucokinase (fragment) | 2 | 2 | 13.2 | 21.8 | 204 | 3.1 | 5.31E-04 | 11,465,000 | 18,413,000 | 0.69 | |
| AL1B1 | ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial | 6 | 5 | 17.0 | 57.2 | 517 | 26.0 | 0.00E+00 | 69,821,000 | 196,750,000 | 0.45 | |
| ALDH2 | ALDH2 | Aldehyde dehydrogenase, mitochondrial | 18 | 17 | 48.4 | 56.4 | 517 | 68.0 | 0.00E+00 | 812,240,000 | 1,822,600,000 | 0.44 | |
| AL3A2 | ALDH3A2 | Aldehyde dehydrogenase family 3 member A2 | 10 | 10 | 26.0 | 51.9 | 461 | 30.5 | 0.00E+00 | 225,000,000 | 394,360,000 | 0.55 | |
| AL9A1 | ALDH9A1 | 4-Trimethylaminobutyraldehyde dehydrogenase | 18 | 18 | 39.3 | 53.8 | 494 | 77.3 | 0.00E+00 | 529,020,000 | 1,322,400,000 | 0.48 | |
| A0A024QZ64 | ALDOC | Fructose-bisphosphate aldolase | 12 | 8 | 45.1 | 39.5 | 364 | 109.3 | 0.00E+00 | 1,104,800,000 | 2,650,700,000 | 0.43 | |
| H0YDD4 | DLAT | Acetyltransferase component of pyruvate dehydrogenase complex (fragment) | 8 | 8 | 21.1 | 51.2 | 479 | 74.8 | 0.00E+00 | 530,720,000 | 1,251,100,000 | 0.46 | |
| A0A024R713 | DLD | Dihydrolipoyl dehydrogenase | 13 | 13 | 37.7 | 48.9 | 459 | 35.1 | 0.00E+00 | 632,170,000 | 1,843,800,000 | 0.52 | |
| Q6FHV6 | ENO2 | ENO2 protein | 13 | 11 | 50.2 | 47.3 | 434 | 175.6 | 0.00E+00 | 618,190,000 | 2,887,100,000 | 0.26 | |
| ENOB | ENO3 | Beta-enolase | 4 | 2 | 19.4 | 47.0 | 434 | 6.7 | 0.00E+00 | 215,810,000 | 482,340,000 | 0.59 | |
| B4DG62 | HK1 | cDNA FLJ56506, highly similar to hexokinase-1 | 29 | 22 | 36.0 | 102.3 | 915 | 109.9 | 0.00E+00 | 1,617,000,000 | 4,075,800,000 | 0.53 | |
| HKDC1 | HKDC1 | Hexokinase HKDC1 | 15 | 11 | 17.7 | 102.5 | 917 | 57.9 | 0.00E+00 | 132,850,000 | 568,430,000 | 0.30 | |
| PCKGC | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 8 | 6 | 17.0 | 69.2 | 622 | 15.3 | 0.00E+00 | 1,267,700 | 160,370,000 | 0.07 | |
| A0A384MTT2 | PCK2 | Epididymis secretory sperm binding protein | 12 | 10 | 25.8 | 70.7 | 640 | 61.9 | 0.00E+00 | 403,190,000 | 1,032,500,000 | 0.56 | |
| A0A024RBX9 | PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha | 11 | 11 | 35.1 | 43.3 | 390 | 102.8 | 0.00E+00 | 457,490,000 | 1,353,000,000 | 0.49 | |
| PFKAL | PFKL | ATP-dependent 6-phosphofructokinase, liver type | 16 | 12 | 27.1 | 85.0 | 780 | 161.1 | 0.00E+00 | 1,242,500,000 | 2,567,300,000 | 0.52 | |
| A0A024R0Y5 | PFKM | ATP-dependent 6-phosphofructokinase | 20 | 17 | 35.5 | 85.2 | 780 | 323.3 | 0.00E+00 | 1,677,600,000 | 3,768,800,000 | 0.47 | |
| Q6P6D7 | PGAM1 | Phosphoglycerate mutase | 15 | 15 | 70.5 | 28.8 | 254 | 226.1 | 0.00E+00 | 11,906,000,000 | 30,409,000,000 | 0.36 | |
| A0A3B3ITK7 | PGM1 | Phosphoglucomutase-1 | 18 | 18 | 40.2 | 64.0 | 584 | 109.1 | 0.00E+00 | 721,450,000 | 1,641,900,000 | 0.43 | |
| PGM2 | PGM2 | Phosphoglucomutase-2 | 9 | 9 | 19.8 | 68.3 | 612 | 13.7 | 0.00E+00 | 144,180,000 | 423,580,000 | 0.40 | |
| A0A024R5Z9 | PKM2 | Pyruvate kinase | 39 | 1 | 71.6 | 58.1 | 531 | − 2.0 | 1.00E+00 | 35,541,000 | 125,430,000 | 0.54 | |
| Kreb’s cycle | ODPB | PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 9 | 9 | 34.0 | 39.2 | 359 | 67.1 | 0.00E+00 | 407,280,000 | 1,649,500,000 | 0.46 |
| B4DJV2 | CS | Citrate synthase | 15 | 14 | 43.0 | 50.4 | 453 | 76.8 | 0.00E+00 | 2,428,500,000 | 5,338,700,000 | 0.45 | |
| IDHP | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial | 18 | 17 | 48.0 | 50.9 | 452 | 174.3 | 0.00E+00 | 1,281,200,000 | 2,994,300,000 | 0.46 | |
| IDH3A | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 10 | 10 | 36.4 | 34.5 | 316 | 90.6 | 0.00E+00 | 268,600,000 | 1,119,300,000 | 0.40 | |
| A0A087WZN1 | IDH3B | Isocitrate dehydrogenase [NAD] subunit, mitochondrial | 8 | 8 | 26.6 | 42.4 | 387 | 26.8 | 0.00E+00 | 142,630,000 | 477,180,000 | 0.41 | |
| OGDHL | OGDHL | 2-Oxoglutarate dehydrogenase-like, mitochondrial | 10 | 5 | 10.9 | 114.5 | 1010 | 12.7 | 0.00E+00 | 17,707,000 | 119,970,000 | 0.56 | |
| O75944 | ACON | Aconitase (fragment) | 16 | 3 | 33.5 | 65.3 | 600 | 12.1 | 0.00E+00 | 0 | 48,304,000 | − | |
| A0A384MTT2 | PCK2 | Epididymis secretory sperm binding protein | 12 | 10 | 25.8 | 70.7 | 640 | 61.9 | 0.00E+00 | 403,190,000 | 1,032,500,000 | 0.56 | |
| Q0QF37 | MDH2 | Malate dehydrogenase (fragment) | 17 | 17 | 70.5 | 32.0 | 305 | 323.3 | 0.00E+00 | 5,856,200,000 | 14,406,000,000 | 0.42 | |
| A0A024R325 | SUCLG2 | Succinate–CoA ligase [GDP-forming] subunit beta, mitochondrial | 8 | 8 | 25.5 | 46.5 | 432 | 42.3 | 0.00E+00 | 232,210,000 | 779,800,000 | 0.41 | |
| Q71UF1 | ACO2 | Aconitate hydratase, mitochondrial | 24 | 0 | 38.6 | 85.6 | 780 | − 2.0 | 1.00E+00 | 0 | 12,950,000 | − | |
| A0A024R1Y2 | ACLY | ATP-citrate synthase | 37 | 37 | 42.4 | 119.8 | 1091 | 183.5 | 0.00E+00 | 2,033,900,000 | 4,490,700,000 | 0.46 | |
| H0YDD4 | DLAT | Acetyltransferase component of pyruvate dehydrogenase complex (fragment) | 8 | 8 | 21.1 | 51.2 | 479 | 74.8 | 0.00E+00 | 530,720,000 | 1,251,100,000 | 0.46 | |
| A0A024R713 | DLD | Dihydrolipoyl dehydrogenase | 13 | 13 | 37.7 | 48.9 | 459 | 35.1 | 0.00E+00 | 632,170,000 | 1,843,800,000 | 0.52 | |
| Q6IBS5 | DLST | DLST protein | 7 | 7 | 20.5 | 48.8 | 453 | 44.5 | 0.00E+00 | 601,540,000 | 1,338,700,000 | 0.53 | |
| A0A0S2Z4C3 | FH | Epididymis secretory sperm binding protein (fragment) | 14 | 14 | 35.5 | 54.6 | 510 | 161.7 | 0.00E+00 | 1,498,700,000 | 3,849,500,000 | 0.43 | |
| IDH3G | IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial | 7 | 7 | 27.7 | 42.8 | 393 | 42.3 | 0.00E+00 | 55,446,000 | 230,380,000 | 0.54 | |
| ODO1 | OGDH | 2-Oxoglutarate dehydrogenase, mitochondrial | 23 | 18 | 31.5 | 115.9 | 1023 | 82.1 | 0.00E+00 | 325,090,000 | 949,610,000 | 0.43 | |
| A0A494C101 | PC | Pyruvate carboxylase, mitochondrial (fragment) | 2 | 2 | 5.2 | 53.5 | 483 | 3.0 | 7.83E-04 | 3,454,600 | 19,685,000 | 0.28 | |
| PCKGC | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 8 | 6 | 17.0 | 69.2 | 622 | 15.3 | 0.00E+00 | 1,267,700 | 160,370,000 | 0.07 | |
| A0A024RBX9 | PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha | 11 | 11 | 35.1 | 43.3 | 390 | 102.8 | 0.00E+00 | 457,490,000 | 1,353,000,000 | 0.49 | |
| A0A024QZ30 | SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | 20 | 20 | 44.9 | 72.7 | 664 | 200.0 | 0.00E+00 | 1,096,500,000 | 2,950,800,000 | 0.44 | |
| SDHB | SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 6 | 2 | 24.3 | 31.6 | 280 | 17.3 | 0.00E+00 | 143,030,000 | 516,360,000 | 0.37 | |
| D3DVH1 | SDHC | Succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa, isoform CRAa | 3 | 3 | 35.2 | 11.3 | 105 | 6.8 | 0.00E+00 | 68,060,000 | 130,150,000 | 0.46 | |
| B7ZAF6 | SUCLA2 | Succinate–CoA ligase [ADP-forming] subunit beta, mitochondrial | 9 | 9 | 36.2 | 36.0 | 329 | 127.1 | 0.00E+00 | 114,900,000 | 726,200,000 | 0.33 | |
| Q6IAL5 | SUCLG1 | Succinate–CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 8 | 8 | 30.3 | 35.0 | 333 | 45.9 | 0.00E+00 | 261,580,000 | 1,105,700,000 | 0.34 | |
| Oxidative phosphorylation | D2Y6X2 | ND5 | NADH dehydrogenase subunit 5 (fragment) | 1 | 1 | 26.8 | 4.5 | 41 | 3.2 | 5.33E-04 | 4,125,200 | 24,591,000 | 0.41 |
| A0A1B0TCA9 | CYTB | Cytochrome b (fragment) | 1 | 1 | 2.8 | 35.7 | 318 | 2.2 | 3.59E-03 | 53,396,000 | 59,765,000 | 0.55 | |
| Q567R0 | UQCRH | UQCRH protein | 1 | 1 | 21.2 | 10.0 | 85 | 37.0 | 0.00E+00 | 252,050,000 | 546,900,000 | 0.51 | |
| C9J8T6 | COX17 | Cytochrome c oxidase copper chaperone | 1 | 1 | 16.3 | 10.9 | 98 | 3.5 | 0.00E+00 | 7,643,200 | 53,020,000 | 0.36 | |
| Q6FGA0 | COX7A2L | COX7A2L protein | 2 | 2 | 19.3 | 12.6 | 114 | 3.2 | 5.34E-04 | 22,802,000 | 1,280,400 | 17.81 | |
| U3L4G0 | ATP6 | ATP synthase subunit a | 2 | 2 | 11.1 | 24.8 | 226 | 3.7 | 0.00E+00 | 193,600,000 | 355,900,000 | 0.73 | |
| X2C5C9 | COX1 | Cytochrome c oxidase subunit 1 | 2 | 2 | 5.8 | 41.6 | 379 | 3.0 | 7.89E-04 | 21,347,000 | 57,543,000 | 0.38 | |
| A0A346M047 | COX2 | Cytochrome c oxidase subunit II (fragment) | 7 | 1 | 46.4 | 17.0 | 151 | 22.8 | 0.00E+00 | 1,046,600,000 | 2,406,000,000 | 0.38 | |
| H3BNI4 | ATP6V0C | V-type proton ATPase proteolipid subunit | 1 | 1 | 8.9 | 11.6 | 112 | − 2.0 | 1.00E+00 | 11,819,000 | 33,788,000 | 0.47 | |
| Q496I0 | COX7A2 | COX7A2 protein | 2 | 2 | 27.7 | 9.4 | 83 | 10.2 | 0.00E+00 | 223,550,000 | 687,660,000 | 0.32 | |
| COX6C | COX6C | Cytochrome c oxidase subunit 6C | 2 | 2 | 40.0 | 8.8 | 75 | 5.0 | 0.00E+00 | 24,314,000 | 57,899,000 | 0.34 | |
| COX41 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 8 | 8 | 45.6 | 19.6 | 169 | 28.4 | 0.00E+00 | 1,057,000,000 | 2,524,600,000 | 0.40 | |
| AT12A | ATP12A | Potassium-transporting ATPase alpha chain 2 | 6 | 1 | 5.3 | 115.5 | 1039 | − 2.0 | 1.00E+00 | 25,608,000 | 48,153,000 | 0.50 | |
| ATPG | ATP5F1C | ATP synthase subunit gamma, mitochondrial | 11 | 1 | 36.8 | 32.2 | 291 | 102.1 | 0.00E+00 | 610,730,000 | 1,752,800,000 | 0.61 | |
| ATPD | ATP5F1D | ATP synthase subunit delta, mitochondrial | 3 | 3 | 22.6 | 17.5 | 168 | 22.0 | 0.00E+00 | 173,290,000 | 378,660,000 | 0.59 | |
| ATP5I | ATP5ME | ATP synthase subunit e, mitochondrial | 4 | 4 | 42.0 | 7.9 | 69 | 10.4 | 0.00E+00 | 139,860,000 | 416,580,000 | 0.28 | |
| ATPK | ATP5MF | ATP synthase subunit f, mitochondrial | 3 | 3 | 39.4 | 10.9 | 94 | 15.6 | 0.00E+00 | 146,600,000 | 369,660,000 | 0.57 | |
| E9PN17 | ATP5MG | ATP synthase subunit g, mitochondrial | 3 | 3 | 48.7 | 8.5 | 76 | 15.1 | 0.00E+00 | 501,810,000 | 1,039,800,000 | 0.45 | |
| Q5QNZ2 | ATP5PB | ATP synthase F(0) complex subunit B1, mitochondrial | 9 | 9 | 49.7 | 22.3 | 195 | 323.3 | 0.00E+00 | 1,074,900,000 | 2,486,300,000 | 0.46 | |
| ATP5H | ATP5PD | ATP synthase subunit d, mitochondrial | 8 | 8 | 59.0 | 18.5 | 161 | 78.9 | 0.00E+00 | 525,070,000 | 965,510,000 | 0.39 | |
| ATPO | ATP5PO | ATP synthase subunit O, mitochondrial | 8 | 8 | 54.5 | 23.3 | 213 | 82.2 | 0.00E+00 | 1,495,600,000 | 3,024,300,000 | 0.56 | |
| VPP1 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1 | 10 | 9 | 14.8 | 95.8 | 831 | 51.9 | 0.00E+00 | 98,038,000 | 557,300,000 | 0.35 | |
| R4GN72 | ATP6V0D1 | V-type proton ATPase subunit d 1 | 7 | 7 | 25.5 | 31.7 | 274 | 21.2 | 0.00E+00 | 258,530,000 | 806,720,000 | 0.31 | |
| VATA | ATP6V1A | V-type proton ATPase catalytic subunit A | 18 | 18 | 41.3 | 68.3 | 617 | 277.6 | 0.00E+00 | 1,191,800,000 | 3,218,800,000 | 0.37 | |
| VATB2 | ATP6V1B2 | V-type proton ATPase subunit B, brain isoform | 15 | 15 | 45.6 | 56.5 | 511 | 127.2 | 0.00E+00 | 583,390,000 | 2,310,600,000 | 0.35 | |
| A0A024R9I0 | ATP6V1C1 | V-type proton ATPase subunit C | 11 | 11 | 27.7 | 43.9 | 382 | 36.3 | 0.00E+00 | 105,790,000 | 524,300,000 | 0.36 | |
| Q53Y06 | ATP6V1E1 | ATPase, H+ transporting, lysosomal 31 kDa, V1 subunit E isoform 1 | 6 | 6 | 25.2 | 26.1 | 226 | 38.1 | 0.00E+00 | 226,190,000 | 457,540,000 | 0.46 | |
| A4D1K0 | ATP6V1F | V-type proton ATPase subunit F | 3 | 3 | 33.6 | 13.4 | 119 | 7.7 | 0.00E+00 | 72,747,000 | 287,010,000 | 0.62 | |
| A0A024R883 | ATP6V1G1 | V-type proton ATPase subunit G | 3 | 3 | 29.7 | 13.8 | 118 | 22.3 | 0.00E+00 | 121,660,000 | 150,890,000 | 0.58 | |
| A0A024R7X3 | ATP6V1H | V-type proton ATPase subunit H | 6 | 6 | 17.6 | 54.2 | 465 | 26.3 | 0.00E+00 | 33,783,000 | 166,330,000 | 0.37 | |
| COX15 | COX15 | Cytochrome c oxidase assembly protein COX15 homolog | 4 | 4 | 11.0 | 46.0 | 410 | 6.5 | 0.00E+00 | 52,507,000 | 160,350,000 | 0.47 | |
| A0A343FH12 | COX3 | Cytochrome c oxidase subunit 3 | 2 | 2 | 13.4 | 30.0 | 261 | 3.6 | 0.00E+00 | 251,800,000 | 620,670,000 | 0.40 | |
| H3BNX8 | COX5A | Cytochrome c oxidase subunit 5A, mitochondrial | 3 | 3 | 20.3 | 17.2 | 153 | 7.1 | 0.00E+00 | 489,640,000 | 1,451,700,000 | 0.67 | |
| COX5B | COX5B | Cytochrome c oxidase subunit 5B, mitochondrial | 4 | 4 | 24.8 | 13.7 | 129 | 9.1 | 0.00E+00 | 237,370,000 | 754,990,000 | 0.33 | |
| CX6B1 | COX6B1 | Cytochrome c oxidase subunit 6B1 | 4 | 4 | 57.0 | 10.2 | 86 | 32.2 | 0.00E+00 | 278,190,000 | 1,028,600,000 | 0.28 | |
| CY1 | CYC1 | Cytochrome c1, heme protein, mitochondrial | 8 | 8 | 31.1 | 34.5 | 315 | 80.4 | 0.00E+00 | 426,190,000 | 876,770,000 | 0.51 | |
| Q5T1Z0 | LHPP | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase | 1 | 1 | 14.2 | 22.9 | 212 | 1.8 | 9.74E-03 | 0 | 20,832,000 | − | |
| D8VCQ0 | ND4 | NADH-ubiquinone oxidoreductase chain 4 (fragment) | 1 | 1 | 3.8 | 29.6 | 266 | 2.2 | 3.36E-03 | 3,604,800 | 7,493,900 | 0.44 | |
| Q7Z518 | NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | 5 | 5 | 18.6 | 40.7 | 354 | 14.3 | 0.00E+00 | 46,879,000 | 194,320,000 | 0.31 | |
| NDUAD | NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | 4 | 4 | 33.3 | 16.7 | 144 | 12.4 | 0.00E+00 | 43,461,000 | 261,780,000 | 0.34 | |
| NDUA2 | NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | 2 | 2 | 31.3 | 10.9 | 99 | 5.9 | 0.00E+00 | 35,677,000 | 165,030,000 | 0.24 | |
| NDUA4 | NDUFA4 | Cytochrome c oxidase subunit NDUFA4 | 2 | 2 | 27.2 | 9.4 | 81 | 30.4 | 0.00E+00 | 99,542,000 | 1,041,400,000 | 0.28 | |
| NDUA5 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 3 | 3 | 35.3 | 13.5 | 116 | 20.4 | 0.00E+00 | 126,370,000 | 440,540,000 | 0.46 | |
| NDUA8 | NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | 6 | 6 | 48.8 | 20.1 | 172 | 15.3 | 0.00E+00 | 75,771,000 | 226,560,000 | 0.33 | |
| NDUA9 | NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | 9 | 9 | 30.5 | 38.4 | 338 | 22.1 | 0.00E+00 | 38,134,000 | 212,250,000 | 0.38 | |
| H3BNK3 | NDUFAB1 | Acyl carrier protein (fragment) | 1 | 1 | 12.6 | 12.1 | 111 | 20.7 | 0.00E+00 | 91,383,000 | 220,140,000 | 0.41 | |
| NDUB1 | NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | 3 | 3 | 34.5 | 7.0 | 58 | 5.4 | 0.00E+00 | 52,572,000 | 104,780,000 | 0.46 | |
| H3BPJ9 | NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | 4 | 4 | 31.7 | 19.3 | 161 | 22.9 | 0.00E+00 | 68,400,000 | 353,550,000 | 0.41 | |
| NDUBB | NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | 3 | 3 | 33.5 | 17.9 | 158 | 16.2 | 0.00E+00 | 40,408,000 | 192,110,000 | 0.31 | |
| C9JKQ2 | NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (fragment) | 2 | 2 | 27.7 | 7.6 | 65 | 3.0 | 7.84E-04 | 19,660,000 | 91,217,000 | 0.33 | |
| NDUB4 | NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | 2 | 2 | 21.7 | 15.2 | 129 | 6.3 | 0.00E+00 | 15,764,000 | 129,660,000 | 0.40 | |
| NDUB8 | NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | 3 | 3 | 22.6 | 21.8 | 186 | 9.8 | 0.00E+00 | 38,897,000 | 134,110,000 | 0.34 | |
| A0A3B3IT57 | NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | 3 | 3 | 34.1 | 17.2 | 138 | 13.8 | 0.00E+00 | 47,909,000 | 178,250,000 | 0.26 | |
| E5KRK5 | NDUFS1 | Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit | 18 | 18 | 33.4 | 79.5 | 727 | 146.6 | 0.00E+00 | 87,635,000 | 1,424,000,000 | 0.27 | |
| NDUS2 | NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | 9 | 9 | 26.6 | 46.4 | 406 | 23.2 | 0.00E+00 | 255,210,000 | 555,800,000 | 0.40 | |
| NDUS3 | NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | 8 | 8 | 39.4 | 30.2 | 264 | 62.5 | 0.00E+00 | 303,550,000 | 1,007,100,000 | 0.38 | |
| H0Y9M8 | NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (fragment) | 1 | 1 | 12.9 | 13.5 | 116 | 4.1 | 0.00E+00 | 22,776,000 | 124,620,000 | 0.20 | |
| Q6IBA0 | NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15 kDa (NADH-coenzyme Q reductase) | 5 | 5 | 45.3 | 12.5 | 106 | 6.0 | 0.00E+00 | 13,539,000 | 83,631,000 | 0.36 | |
| B7Z4P1 | NDUFS7 | cDNA FLJ58024, highly similar to NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial | 1 | 1 | 6.1 | 15.8 | 148 | 2.2 | 3.38E-03 | 89,666,000 | 146,530,000 | 1.06 | |
| E9PKH6 | NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (fragment) | 2 | 2 | 19.6 | 15.9 | 138 | 6.0 | 0.00E+00 | 25,384,000 | 70,988,000 | 0.38 | |
| G3V0I5 | NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 4 | 4 | 12.3 | 50.1 | 457 | 9.4 | 0.00E+00 | 25,550,000 | 98,424,000 | 0.34 | |
| Q9UEH5 | NDUFV2 | 24-kDa subunit of complex I (fragment) | 4 | 4 | 23.4 | 25.4 | 231 | 16.5 | 0.00E+00 | 120,810,000 | 407,130,000 | 0.33 | |
| IPYR2 | PPA2 | Inorganic pyrophosphatase 2, mitochondrial | 9 | 3 | 38.6 | 37.9 | 334 | 38.4 | 0.00E+00 | 815,730,000 | 1,743,800,000 | 0.42 | |
| A0A024QZ30 | SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | 20 | 20 | 44.9 | 72.7 | 664 | 200.0 | 0.00E+00 | 1,096,500,000 | 2,950,800,000 | 0.44 | |
| SDHB | SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 6 | 2 | 24.3 | 31.6 | 280 | 17.3 | 0.00E+00 | 143,030,000 | 516,360,000 | 0.37 | |
| D3DVH1 | SDHC | Succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa, isoform CRAa | 3 | 3 | 35.2 | 11.3 | 105 | 6.8 | 0.00E+00 | 68,060,000 | 130,150,000 | 0.46 | |
| A0A024R5E5 | TCIRG1 | V-type proton ATPase subunit a | 8 | 7 | 11.8 | 93.0 | 830 | 29.0 | 0.00E+00 | 139,450,000 | 227,300,000 | 0.73 | |
| QCR9 | UQCR10 | Cytochrome b-c1 complex subunit 9 | 2 | 2 | 38.1 | 7.3 | 63 | 12.3 | 0.00E+00 | 260,330,000 | 491,890,000 | 0.52 | |
| QCR7 | UQCRB | Cytochrome b-c1 complex subunit 7 | 4 | 4 | 36.0 | 13.5 | 111 | 13.2 | 0.00E+00 | 208,330,000 | 523,300,000 | 0.37 | |
| QCR1 | UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | 15 | 15 | 45.8 | 52.6 | 480 | 205.2 | 0.00E+00 | 1,326,400,000 | 3,772,100,000 | 0.43 | |
| QCR2 | UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | 15 | 15 | 43.9 | 48.4 | 453 | 142.7 | 0.00E+00 | 1,718,400,000 | 3,636,100,000 | 0.43 | |
| A0A384NPX8 | UQCRFS1 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | 4 | 4 | 15.3 | 29.7 | 274 | 16.3 | 0.00E+00 | 79,904,000 | 211,540,000 | 0.34 | |
| QCR8 | UQCRQ | Cytochrome b-c1 complex subunit 8 | 2 | 2 | 26.7 | 8.3 | 75 | 8.3 | 0.00E+00 | 88,536,000 | 237,890,000 | 0.57 | |
| Lactate shuttle | B4E106 | MCT1 | cDNA FLJ53399, highly similar to monocarboxylate transporter 1 | 2 | 2 | 6.7 | 51.9 | 480 | 21.3 | 0.00E+00 | 23,799,000 | 115,420,000 | 0.53 |
| MOT4 | MCT4 | Monocarboxylate transporter 4 | 7 | 7 | 16.1 | 49.469 | 465 | 43.453 | 0.00E+00 | 818,320,000 | 2,103,700,000 | 0.38 |
− means the protein expressed in the L group but not in the H group. + means the protein expressed in the H group but not in the L group. / means the protein with expressed value 0 in both the H and L groups. Ratio H/L means the ratio of the ivermectin-treated group (SILAC: H) to the no ivermectin-treated group (SILAC: L)