Table 1 .
Demographics, clinical characteristics, treatments, and outcomes among patients who were or were not weaned from NIPPV.
| Variables | Total | Patients weaned from NIPPV | Patients not weaned from NIPPV | P value |
|---|---|---|---|---|
| No | 50 (100%) | 22 (44%) | 28 (56%) | |
| Age, years, mean (SD) | 74.6 (11) | 71 (11.4) | 77.5 (9.9) | 0.0361 |
| Female, n | 17 (34%) | 6 (27.3%) | 11 (39.3%) | 0.5556 |
| Comorbidities | ||||
| Atrial fibrillation, n° | 14 (28%) | 5 (22.7%) | 9 (32.1%) | 0.6754 |
| Cardiovascular disease, n | 22 (44%) | 8 (36.4%) | 14 (50%) | 0.4982 |
| Chronic kidney disease, n | 10 (20%) | 2 (9.1%) | 8 (28.6%) | 0.1535 |
| Cognitive impairment, n | 7 (14%) | 2 (9.1%) | 5 (17.9%) | 0.4444 |
| COPD, n | 10 (20%) | 4 (18.2%) | 6 (21.4%) | 1 |
| Diabetes mellitus, n | 12 (24%) | 5 (22.7%) | 7 (25%) | 0.8518 |
| Hypertension, n | 28 (56%) | 12 (54.5%) | 16 (57.1%) | 0.8543 |
| Immunodeficiency, n | 3 (6%) | 2 (9.1%) | 1 (3.6%) | 0.5757 |
| Malignancy, n | 6 (12%) | 1 (4.5%) | 5 (17.9%) | 0.2109 |
| Stroke, n | 8 (16%) | 2 (9.1%) | 6 (21.4%) | 0.4391 |
| Number of comorbidities, mean (SD) | 2.4 (1.5) | 2 (1.6) | 2.8 (1.3) | 0.0569 |
| SOFA score, mean (SD) | 3.1 (1.2) | 2.9 (1) | 3.3 (1.4) | 0.2635 |
| PaO2/FiO2 before NIPPV, mm Hg, mean (SD) | 130.1 (63.5) | 136.8 (57.9) | 124.9 (68.2) | 0.5164 |
| PaO2/FiO2 24–48 h after NIPPV, mm Hg, mean (SD) | 148.3 (63.5) | 183.2 (64.7) | 120.8 (70.2) | 0.0022 |
| NIPPV modality | ||||
| NIPPV BiPAP, n | 25 (50%) | 8 (36.4%) | 17 (60.7%) | 0.1543 |
| NIPPV CPAP, n | 25 (50%) | 14 (63.6%) | 11 (39.3%) | 0.1543 |
| NIPPV duration, hours, mean (SD) | 187 (181) | 264 (223.3) | 126.4 (109.8) | 0.0063 |
| Treatments | ||||
| Treatment with corticosteroids, n | 35 (70%) | 19 (86.4%) | 16 (57.1%) | 0.0325 |
| Treatment with tocilizumab, n | 17 (34%) | 12 (54.5%) | 5 (17.9%) | 0.0156 |
| Treatment with antibiotics, n | 46 (92%) | 20 (90.9%) | 26 (92.9%) | 1 |
| DNI order, n | 25 (50%) | 6 (27.3%) | 19 (67.9%) | 0.0103 |
| Outcomes | ||||
| Duration of hospital stay, days, mean (SD) | 19.6 (14.5) | 23 (11) | 15.3 (13.1) | 0.0319 |
| In-hospital death, n | 25 (50%) | 3 (13.6%) | 22 (78.6%) | < 0.0001 |