Skip to main content
. Author manuscript; available in PMC: 2020 Nov 22.
Published in final edited form as: J Neurochem. 2018 Dec 5;149(1):54–72. doi: 10.1111/jnc.14608

Figure 5. Treatment with ANDRO or Li increased the in vivo uptake of glucose.

Figure 5.

After the indicated treatments, radioactive glucose was tail-vein injected, and 15 min later, glucose uptake in the whole brain (A), hippocampus (B), and cortex (C) was measured. The APP/PS1 mice exhibited decreased uptake of glucose. Wnt agonists improved glucose uptake in the APP/PS1 animals. Data from APP/PS1 mice (under blue line). The effects of the various treatments on the mRNA levels of the GLUT 1 (D), 3 (E) and 4 (F) glucose transporter proteins, which are known to be affected in AD. Data represent the mean ± SEM of n = 6 (number of animals for treatment), *p < 0.05; **p < 0.01, Bonferroni test.