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. Author manuscript; available in PMC: 2020 Nov 22.
Published in final edited form as: J Neurochem. 2018 Dec 5;149(1):54–72. doi: 10.1111/jnc.14608

Figure 6. Treatment with ANDRO and Li induced the utilization of glucose promoting the generation of ATP and NAPDH.

Figure 6.

Parameters related to glucose metabolism, including the glycolytic rate, were measured in the brains of control or treated mice, Data from APP/PS1 mice (under blue line). (A) Treatment with ANDRO or Li stimulated the glycolytic rate. Treatment with ANDRO or Li stimulated the enzymatic activity of two check point proteins of glycolysis: HK (B) and PFK (C). ANDRO and Li stimulated PPP (D) and the activity of the first control point of the PPP pathway: G6PD (E). Effects of treatments on the levels of AMPK, an important metabolic sensor of glucose metabolism (F). ATP (G) and the ATP/ADP ratio (H) were measured to correlate the previous parameters with the energy status of cells. ANDRO and Li restored the levels of both parameters in APP/PS1 mice. Data represent the mean ± SEM of n = 3 (independent experiments), each performed in triplicate. *p < 0.05; **p < 0.01, Bonferroni test.