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. Author manuscript; available in PMC: 2020 Nov 22.
Published in final edited form as: J Neurochem. 2018 Dec 5;149(1):54–72. doi: 10.1111/jnc.14608

Figure 8. General model of Wnt-Glucose interactions in the brain.

Figure 8.

Treatment with ANDRO/Li triggers activation of canonical Wnt signaling promoting the activations of several Wnt target genes, many related to cellular metabolism. Activation of Wnt signaling also enhances several glucose-related parameters, including glucose uptake, the glycolytic rate, and the production of ATP. Wnt signaling stimulates the enzymatic activities of several key metabolic enzymes and sensors such as hexokinase (HK), phosphofructokinase (PFK), and AMP-activated protein kinase (AMPK). The interaction of Wnt signaling and glucose metabolism promotes the recovery of cognitive performance in a mouse model of Alzheimer’s disease.