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. 2020 Nov 18;14:5077–5085. doi: 10.2147/DDDT.S275148

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© 2020 Wang et al.

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Acacetin induces apoptosis by activating the ROS/JNK signaling cascade in OS cells. Cells were preincubated with SP600125 (30 μM) or GSH (5 mM) for 2 h and then treated with acacetin for 24 h. (A) Cell viability was measured by CCK8 assay. (B) Flow cytometric analysis demonstrated that GSH and SP600125 attenuated the acacetin-induced apoptosis. Results are presented as the mean ± SD from three independent experiments. (C and D) The expression of apoptosis-related protein was measured by Western blotting. *P<0.05 and **P<0.001, significantly different compared with control.