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. 2020 Nov 16;23(1):21–35. doi: 10.1016/j.neo.2020.11.005

Figure 1.

Fig. 1

Histological and mutational status of CRC PDX. (A) Staining of the original patient tissue paired to the corresponding PDX tissue. Representative patient/PDX pairs were chosen: Co10194 is derived from a primary colon carcinoma sample, Co9978 from a rectum sample, Co7809 was derived from a liver metastasis and Co7475 is derived from a lung metastasis. Upper panel, original patient tissue: HE staining; panel 2 to 4, PDX tissue: HE staining; IF staining for human nuclei, DAPI = blue; human nuclei = orange (Cy3); IHC staining for EpCAM. (B) Representative HE staining of consecutive passages of PDX Co5854 and Co11061 demonstrate characteristic phenotype of human colorectal carcinoma. Scale bar represents 100 µm. (C) Summary of mutational status of all PDX models.