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. 2020 Nov 16;23(1):21–35. doi: 10.1016/j.neo.2020.11.005

Table 3.

Patient tumor and matched normal tissue, paired with tissue from different, sequential passages of the corresponding PDX models was sequenced using the TruSeq Amplicon – Cancer Panel. 212 amplicons in 48 oncogenes were targeted. The results obtained for the main oncogenes are summarized in the table (AA = amino acid, n.a. = not analyzed).

Mutation detected, (AA mutation)
Patient or PDX, passage APC BRAF EGFR KRAS MET PIK3CA TP53
Co9587, normal tissue - - - - - - -
Co9587, patient tumor n.a. n.a. n.a. G12D n.a. n.a. n.a.
Co9587, P0 ins1554;R876 - - G12D - del104 -
Co9587, P1 ins1554;R876X - - G12D - del104 -
Co9587, P2 ins1554;R876X - - G12D - del104 -
Co9587, P3 ins1554;R876X - - G12D - del104 -
Co9587, P4 ins1554;R876X - - G12D - del104 -
Co9775 normal tissue - - - - - - -
Co9775, patient tumor - - - G12D - - G245S
Co9775, P0 - - - G12D - - G245S
Co9775, P1 - - - G12D - - G245S
Co9775, P3 - - - G12D - - G245S
Co9775, P4 - - - G12D - - G245S
Co10925 normal tissue - - - - - - -
Co10925,patient tumor E1379X - - - - - -
Co10925, P1 E1379X - - - - - -
Co10925, P2 E1379X - - - - - -
Co10925, P4 E1379X - - - - - -