Fig. 4.

Effects of IL-6 and alcohol on levels of p42/44 MAPK and pp42/44 MAPK in cerebellum of TG and WT mice. a Cerebellum from TG-naïve mice showed reduced p42 and p44 MAPK levels compared to WT-naive mice. There was no effect of alcohol on p42 or p44 MAPK levels in cerebellum of WT-EtOH or TG-EtOH tg mice compared to the respective alcohol-naïve mice of the same genotype. b pp42 and pp44 MAPK levels were increased in cerebellum from TG-naive mice compared to cerebellum from WT-naive mice. There was no effect of alcohol on pp42 or pp44 MAPK levels in cerebellum from WT-EtOH mice, whereas in cerebellum of TG-EtOH mice, p42 and p44 MAPK levels were decreased compared to cerebellum from the naïve group of the same genotype. Representative Western blots are shown above the graphs. ^#Significantly different from WT of the same treatment group. *Significantly different from naive of the same genotype