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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Invest Dermatol. 2020 May 23;141(1):142–151.e6. doi: 10.1016/j.jid.2020.05.080

Figure 1.

Figure 1.

4OHT-treated tumors in K14CreERT:α3flx/flx mice regress with coincident α3β1 loss. Following two-step tumorigenesis, papillomas were treated with 4OHT or vehicle starting at 19 weeks old (Treatment Day 0). (a,b) Graphs, average tumor (a) volume and (b) number per mouse; n=7 mice/group. (c) Backs of mice, 23-weeks old. (d) H&E of paraffin tumor sections; scale bar, 500 μm. (e,f) Tumors were measured and harvested at 3, 7, 10 or 14 days after 4OHT treatment. (e) Graph, average tumor volume; n≥45 papillomas per group, per timepoint. (f) Tumor cryosections co-stained with anti-K14, anti-α3, and DAPI (day 0); n≥13 tumors per group, per timepoint; scale bar, 100 μm. t, tumor cells; s, stroma; k, keratinized region; *, blood vessels. (a,b,e) Mean +/− s.e.m.; two-tailed t-tests; *P<0.05; ns, not significant.