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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Invest Dermatol. 2020 May 23;141(1):142–151.e6. doi: 10.1016/j.jid.2020.05.080

Figure 3.

Figure 3.

GSEA of human SCC with high vs. low ITGA3 gene expression shows enrichment of expression of genes that encode the upregulated α3β1-dependent MK secretome. (a) The α3β1-dependent MK secretome gene set was defined as proteins measured by quantitative MS that showed upregulated secretion in MKα3+ relative to MKα3− cells. GSEA was performed on RNA expression data from high and low ITGA3-expressing SCCs using the α3β1-dependent secretome as the gene set (NES = 2.07, FDR q-value = 0.00). (b) Expression heatmap of genes corresponding to core enrichment of α3β1-dependent MK secretome within high and low ITGA3-expressing SCCs. (c) Subset of genes (asterisked in panel b) from the α3β1-dependent secretome that showed core enrichment; red text indicates those we linked previously to α3β1-dependent MK functions (see text).