Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Induction of DN PKD overexpression reduces PKD activity. (A) Schematic of the recombined Rosa26 locus with dominant negative (DN) PKD1 knock-in controlled by a pCAG promoter and loxP-flanked STOP codon that was excised with Cre. (B) Total PKD1 protein. (C) PKD activity in the control and cardiac DN PKD mice. Data are mean ± SEM, n = 7–9 mice/group.
