Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 9;11:566871. doi: 10.3389/fphys.2020.566871

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Hering, Rahman, Potthoff, Rump and Stegbauer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cellular distribution of adrenoceptors in the nephron and their effects on sodium transporters. Expression of α1-adrenoceptors (pink), α2-adrenoceptors (blue), and β-adrenoceptors (green) along the nephron showing the influence of renal sympathetic neurotransmission on sodium handling. Norepinephrine modulates sodium handling in the proximal (Na+/H+ 1 and 3 Exchange) and distal tubule (NCC and ENaC) by activating α1-adrenoceptors, α2-adrenoceptors, or β-adrenoceptors. Furthermore, α2-adrenoceptor activation within the renal pelvis decreases ARNA, whereas α1-adrenoceptor activation increases ARNA. β-adrenergic receptor activation induces renin release.