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. 2020 Nov 17;13:11855–11867. doi: 10.2147/OTT.S281211

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© 2020 Li et al.

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ITGA5 is the target of miR-27b in TSCC cells. (A) Binding sites between ITGA5 and miR-27b predicted by TargetScan. (B) Luciferase reporter assay indicated that miR-27b targeted the 3ʹ-UTR of ITGA5 mRNA in SCC-9 cells. WT-ITGA5 or MUT-ITGA5 was cotransfected into SCC-9 with miR-27b mimic or the corresponding negative control. (C) Expression levels of ITGA5 and miR-27b were negatively correlated in TCGA-HNSC samples. *Represents P<0.05.