TABLE 4.

Cardiac output ×APOE-ε4 carrier status interaction and stratified models.

	β	95% Confidence interval	p-value
Cardiac output ×APOE-ε4 interaction
Boston Naming Test, 30-Item	0.17	−0.02, 0.35	0.08
Animal Naming	0.06	−0.19, 0.31	0.64
WAIS-IV Coding	0.55	0.08, 1.0	0.02
DKEFS Number Sequencing†	–0.25	−1.6, 1.1	0.72
Executive Function Composite	–0.01	−0.05, 0.03	0.58
Hooper Visual Organization Test	0.09	−0.09, 0.27	0.33
Episodic Memory Composite	0.03	0.0005, 0.06	0.047
Stratified by APOE-ε4 Carriers
Boston Naming Test, 30-Item	0.21	−0.01, 0.43	0.06
Animal Naming	0.08	−0.16, 0.33	0.50
WAIS-IV Coding	0.71	0.17, 1.2	0.01*
DKEFS Number Sequencing†	–0.06	−1.7, 1.5	0.94
Executive Function Composite	0.002	−0.04, 0.04	0.94
Hooper Visual Organization Test	0.14	−0.05, 0.33	0.15
Episodic Memory Composite	0.05	0.02, 0.08	0.004*
Stratified by APOE-ε4 Non-carriers
Boston Naming Test, 30-Item	0.05	−0.01, 0.11	0.12
Animal Naming	0.08	−0.04, 0.20	0.19
WAIS-IV Coding	0.12	−0.07, 0.32	0.22
DKEFS Number Sequencing†	–0.39	−1.0, 0.21	0.21
Executive Function Composite	0.008	−0.005, 0.02	0.24
Hooper Visual Organization Test	0.07	−0.005, 0.14	0.07
Episodic Memory Composite	0.01	−0.002, 0.03	0.10

Neuropsychological performance values represent the difference between last follow-up visit and baseline visit performances. Data presented as interaction term (cardiac output x time to follow-up). Analyses performed on 306 participants. Models were adjusted for age, sex, race/ethnicity, education, body surface area, Framingham Stroke Risk Profile minus age, and APOE-ε4 status. Bolded values represent significant findings. All neuropsychological performance values are total correct excluding timed tasks measured in seconds (s). *Models that meet the significance threshold after applying the Benjamini-Hochberg procedure. ^†Higher values reflect worse performance. APOE-ε4, apolipoprotein E ε4 allele; DKEFS, Delis-Kaplan Executive Function System; WAIS-IV, Wechsler Adult Intelligence Scale, 4th edition.