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. 2020 Nov 9;11:592084. doi: 10.3389/fimmu.2020.592084

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Copyright © 2020 Tang, Zhu, Zhang, Wu, Wang, Weng, Fang, Zheng, Yang, Qiu, Chen, Xu, Zhao and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The biological function of PDE4B in inflammatory bowel diseases by bioinformatics analysis. (A–C) The box plot showed the level of PDE4B between normal samples and IBD samples in GSE36807 cohort (A), GSE9686 cohort (B), and GSE75214 cohort (C). (D–F) GSEA showed that PDE4B played a positive role in “inflammatory response” (D), as well as the “AKT” (E) and “NF-κB” (F) signaling pathways. (G) The box plot showed the correction of PDE4B level, and the infiltration of 22 types of immune cells was determined by the CIBERSORT R package. Data are shown as the mean ± SD. *P < 0.05; **P 0.01; ***P < 0.001; ****P < 0.0001.