Table 1.
Clinical characteristics of AOSD patients in the training and validation set.
| Training set | Validation set | |||||
|---|---|---|---|---|---|---|
| AOSD (n=40) | AOSD (n=26) | |||||
| Active(n=23) | Inactive(n=17) | HC(n=24) | Active(n=18) | Inactive(n=8) | HC(n=16) | |
| Age (Years) | 35 (29,44) |
41 (25.5, 54.5) |
35 (29, 42) |
29.5 (21.75, 53) |
36.5 (27.5, 51.75) |
31.5 (29.8, 34.3) |
| Sex (F/M) | 18/5 | 14/3 | 16/8 | 15/3 | 6/2 | 8/8 |
| Clinical Manifestations |
||||||
| Fever | 19 (82.6) | 0 | 17 (94.4) | 0 | ||
| Arthralgia | 19 (82.6) | 0 | 14 (77.8) | 0 | ||
| Skin rash | 20 (87.0) | 14 (77.8) | 0 | |||
| Sore throat | 9 (39.1) | 0 | 9 (50.0) | 0 | ||
| Lymphadenopathy | 11 (47.8) | 1 (5.9) | 15 (83.3) | 0 | ||
| Splenomegaly | 8 (34.8) | 0 | 9 (50.0) | 0 | ||
| Hepatomegaly | 0 (0) | 0 | 2 (11.1) | 0 | ||
| Myalgia | 6 (26.1) | 0 | 6 (33.3) | 0 | ||
| Pericarditis | 1 (4.3) | 0 | 4 (22.2) | 0 | ||
| Pleuritis | 3 (13.0) | 0 | 5 (27.8) | 0 | ||
| Pneumonia | 5 (21.7) | 0 | 7 (38.9) | 0 | ||
| PAH | 1 (4.3) | 0 | 2 (11.1) | 0 | ||
| Laboratory features | ||||||
| Hemoglobin (g/L) | 111 (104, 129) | 130 (117, 138) | 106 (91, 118) | 126 (111, 127) | ||
| Leukocytes (109/L) | 12.3 (9.0, 18.4) | 8.1 (6.9, 10.1) | 16.5 (11.4, 18.5) | 8.5 (6.5, 10.6) | ||
| Platelets (109/L) | 257 (180, 311) | 178 (148, 221) | 257 (164, 337) | 230 (188, 290) | ||
| ESR (mm/h) | 50 (37, 71) | 18 (15, 32.5) | 86 (70.8, 107.5) | 9.5 (8, 21.5) | ||
| CRP (mg/L) | 34.8 (21.6, 96.3) | 2.1 (1.0, 11.7) | 84.8 (58.9, 110.5) | 2.8 (0.9, 15.5) | ||
| ALT (U/L) | 40 (27, 56) | 21 (13, 32.5) | 65 (20, 86) | 13.5 (8.8, 31.5) | ||
| AST (U/L) | 31 (21, 52) | 19 (16, 35) | 43 (24.5, 85.5) | 17 (14, 27.5) | ||
| Ferritin (ng/mL) | 2218 (1458, 8351) |
815.3 (429.2, 1986) |
10688 (5928, 15852) |
1219 (634.4, 3125) |
||
| ANA positivity | 3 (13.0) | 1 (5.9) | 3 (16.7) | 0 | ||
| RF positivity | 0 | 0 | 0 | 0 | ||
Data are presented as median (IQR) for continuous variables, and as frequency counts (%) for categorical variables. AOSD, adult-onset Still’s disease; HC, healthy control; PAH, pulmonary arterial hypertension; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ANA, antinuclear antibody; RF, rheumatoid factor.