Table 2.
Comparison of the circulating NET levels according to disease manifestations in AOSD patients.
| citH3-DNA | p value | NE-DNA | p value | MPO-DNA | p value | cfDNA | p value | ||
|---|---|---|---|---|---|---|---|---|---|
| Fever | +, n=36 | 20.4 ± 9.2 | 0.0004 | 20.3 ± 5.8 | 0.0093 | 21.9 ± 16.4 | 0.0022 | 91.1 ± 31.8 | <0.0001 |
| -, n=30 | 13.9 ± 4.1 | 16.5 ± 4.9 | 10.8 ± 4.5 | 59.2 ± 10.4 | |||||
| Arthralgia | +, n=33 | 20.3 ± 9.7 | 0.0127 | 19.9 ± 6.3 | 0.0598 | 22.4 ± 17.0 | 0.0073 | 90.4 ± 33.8 | <0.0001 |
| -, n=33 | 14.7 ± 4.2 | 17.2 ± 4.7 | 11.3 ± 4.6 | 62.8 ± 13.8 | |||||
| Skin rash | +, n=34 | 20.6 ± 9.4 | 0.0006 | 20.2 ± 6.1 | 0.0132 | 21.6 ± 16.8 | 0.0128 | 89.8 ± 32.9 | <0.0001 |
| -, n=32 | 14.1 ± 4.1 | 16.8 ± 4.7 | 11.7 ± 5.8 | 62.6 ± 15.5 | |||||
| Sore throat | +, n=18 | 20.5 ± 9.6 | 0.1052 | 20.1 ± 7.4 | 0.3723 | 23.2 ± 19.4 | 0.1712 | 95.5 ± 39.0 | 0.0046 |
| -, n=48 | 16.4 ± 7.0 | 18.0 ± 4.8 | 14.4 ± 9.9 | 69.5 ± 20.9 | |||||
| Myalgia | +, n=13 | 23.4 ± 8.4 | 0.0002 | 17.3 ± 5.7 | 0.4942 | 24.3 ± 16.6 | 0.0431 | 92.1 ± 30.2 | 0.0128 |
| -, n=53 | 16.0 ± 7.2 | 18.9 ± 5.7 | 15.0 ± 12.2 | 72.8 ± 27.9 | |||||
| Lymphadenopathy | +, n=27 | 21.0 ± 10.2 | 0.0135 | 19.9 ± 6.3 | 0.2786 | 23.6 ± 17.4 | 0.0045 | 91.7 ± 36.4 | 0.0018 |
| -, n=39 | 15.1 ± 4.7 | 17.6 ± 5.1 | 12.2 ± 7.3 | 66.1 ± 16.6 | |||||
| Hepatomegaly | +, n=2 | 40.1 ± 0.0 | 0.0056 | 35.5 ± 3.6 | 0.0009 | 47.6 ± 15.0 | 0.0177 | 133.8 ± 1.4 | 0.0084 |
| -, n=64 | 16.8 ± 7.0 | 18.0 ± 4.9 | 15.9 ± 12.5 | 74.8 ± 27.8 | |||||
| Splenomegaly | +, n=17 | 21.3 ± 10.5 | 0.0792 | 21.5 ± 7.1 | 0.0290 | 23.9 ± 18.4 | 0.0439 | 94.2 ± 36.1 | 0.0038 |
| -, n=49 | 16.2 ± 6.5 | 17.5 ± 4.8 | 14.4 ± 10.6 | 70.5 ± 23.8 | |||||
| Pericarditis | +, n=5 | 31.8 ± 14.3 | 0.0248 | 25.6 ± 4.5 | 0.0019 | 44.6 ± 21.8 | 0.0051 | 121.2 ± 52.1 | 0.0325 |
| -, n=61 | 16.3 ± 6.0 | 18.0 ± 5.4 | 14.6 ± 10.0 | 72.9 ± 23.7 | |||||
| Pneumonia | +, n=12 | 21.2 ± 9.1 | 0.1246 | 22.6 ± 6.4 | 0.0035 | 21.9 ± 18.5 | 0.4092 | 96.8 ± 40.0 | 0.0120 |
| -, n=54 | 16.7 ± 7.5 | 17.6 ± 5.2 | 15.4 ± 12.1 | 71.4 ± 24.1 | |||||
| Pleuritis | +, n=8 | 26.8 ± 13.0 | 0.0256 | 24.3 ± 4.5 | 0.0006 | 31.1 ± 24.8 | 0.2572 | 106.7 ± 45.7 | 0.0233 |
| -, n=58 | 16.2 ± 6.1 | 17.8 ± 5.4 | 14.9 ± 10.1 | 72.4 ± 23.9 | |||||
| PAH | +, n=3 | 34.3 ± 10.1 | 0.0015 | 26.6 ± 5.8 | 0.0155 | 35.2 ± 26.5 | 0.3456 | 107.9 ± 38.9 | 0.1015 |
| -, n=63 | 16.7 ± 7.0 | 18.2 ± 5.4 | 16.0 ± 12.4 | 75.1 ± 28.2 |
Levels of circulating NETs are shown as mean ± SD, and differences between two groups were analyzed using the Mann-Whitney U test for nonparametric data.