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. Author manuscript; available in PMC: 2020 Nov 23.
Published in final edited form as: Eur J Anaesthesiol. 2020 Nov;37(11):984–991. doi: 10.1097/EJA.0000000000001250

Figure 1.

Figure 1

(A) Proportion of twin pairs in which the twin exposed to major surgery had a lower cognitive score for all twin pairs and stratified according to the magnitude of intra-pair difference in cognitive score, separately for APOE ε4 carriers (A1) and non-carriers (A2). Above each line is the p-value from the binomial test, which tests whether the proportion equals to 0.5. (B) Bland Altman plot of difference in cognitive score between the twins (twin exposed to major surgery – twin not exposed to major surgery), separately for APOE ε4 carriers (B1) and non-carriers (B2). The solid blue lines represent the mean difference in cognitive score between twins exposed to major surgery and twins without surgery (mean 0.10 (B1) and 0.42 (B2)).