Table 1.
Characteristics of participants from the Study of Middle-Aged and elderly Twins according to APOE ε4 genotyping status, in totals and by surgery exposure group
| Surgical procedure groups |
||||||
|---|---|---|---|---|---|---|
| Characteristics | Totals | Major surgery* | Minor surgery | Knee/hip replacement |
Other surgery | No surgery |
| n (%) | ||||||
| Total genetic sample | 2936(35) | 549(36) | 605(36) | 46(27) | 758(36) | 978(33) |
| APOE ε4 non-carriers | 2013(24) | 370(24) | 412(24) | 32(19) | 526(25) | 673(23) |
| APOE ε4 carriers | 923(11) | 179(12) | 193(11) | 14(8) | 232(11) | 305(10) |
| Sample without genetic information | 5567(65) | 997(64) | 1124(65) | 125(73) | 1334(64) | 1987(67) |
| Female, n (% of all) | ||||||
| APOE ε4 non-carriers | 1148(25) | 272(27) | 219(26) | 19(17) | 312(27) | 326(22) |
| APOE ε4 carriers | 495(11) | 135(13) | 92(11) | 10(9) | 125(11) | 133(9) |
| Sample without genetic information | 2917(64) | 604(60) | 526(63) | 83(74) | 707(62) | 997(68) |
| Age†, year | ||||||
| APOE ε4 non-carriers | 62.2(11.6) | 61.8(11.6) | 60.6(11) | 69.3(10.1) | 62(12.1) | 63.1(11.5) |
| APOE ε4 carriers | 61.9(11.4) | 62.7(11.3) | 59.5(10) | 77.5(3.5) | 61.1(11.8) | 63(11.6) |
| Sample without genetic information | 69.5(11) | 70.8(10.7) | 68(11.1) | 74.1(7.7) | 69.3(11.5) | 69.4(10.8) |
| Cognitive score± | ||||||
| APOE ε4 non-carriers | −1.8(3.6) | −1.7(3.4) | −1.6(3.7) | −3(3.5) | −1.7(3.7) | −2(3.4) |
| APOE ε4 carriers | −1.9(3.7) | −1.8(3.9) | −1.8(3.5) | −3.7(2.8) | −1.8(3.8) | −2(3.5) |
| Sample without genetic information | −3.2(3.9) | −3.7(4) | −2.9(4.1) | −3.4(3.9) | −3.2(4) | −3.1(3.8) |
| Slope in cognitive score± | ||||||
| APOE ε4 non-carriers | −0.78(2.7) | −0.63(2.8) | −0.78(2.7) | −0.77(2.4) | −0.64(2.6) | −0.81(2.7) |
| APOE ε4 carriers | −0.78(2.8) | −0.58(2.8) | −0.79(3.2) | −1.81(2.5) | 0.33(2.5) | −0.84(2.7) |
*
Including cardiac, thoracic, laparotomy, central and peripheral vascular and fracture surgeries.
†
Median (IQR).
±
Mean (SD)