Table 3.

Mean longitudinal 6-10 years differences (slope) in cognitive composite score between participants having major, minor, knee and hip replacement, or other surgeries and the group not exposed to surgery, by APOEε4 status

	Differences in cognitive score (95% CI)*
Surgical procedure groups	n	APOEε4 non-carriers	N	APOEε4 carriers
No surgery	736	Reference	316	Reference
Any surgery	422	0.08 (−0.27 to 0.42)	197	0.08 (−0.45 to 0.61)	p=0.78
Major†	78	0.22 (−0.44 to 0.89)	34	0.11 (−0.90 to 1.11)	p=0.89
Minor	243	0.01 (−0.41 to 0.42)	125	−0.19 (−0.66 to 0.62)	p=0.99
Knee/hip replacement	27	0.89 (−0.85 to 1.02)	12	−1.21 (−2.64 to 0.22)	p=0.26
Other	74	0.14 (−0.49 to 0.78)	26	1.08 (0.09 to 2.08)	p=0.08

^*Multiple linear regression analyses, adjusted for sex and age at intake examination.

^†Including cardiac, thoracic, laparotomy, central and peripheral vascular and fracture surgeries. P-values are for interaction between APOE and surgery APOE = apolipoprotein