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. 2020 Nov 9;14:584161. doi: 10.3389/fnins.2020.584161

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Copyright © 2020 Palermo, Pieroni, Maugeri, Provinciali, Sanna, Bukreeva, Massimi, Catalano, Olbinado, Fratini, Uccelli, Gigli, Kerlero de Rosbo, Balducci and Cedola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nano-XPCT and holo-nano-XPCT permit the visual dissection of vessels in MSC-CS-treated and untreated AD mouse cortex. (A) Nano-XPCT image showing the almost complete occlusion of vessel lumen by Aβ deposits in vehicle-treated AD mouse brain. The image was acquired at ID16, ESRF. (B) Holo-nano-XPCT image showing cleaner vessels in the brain of AD mouse treated with MSC-CS. (C) Nano-XPCT image of vessels in a healthy wild-type mouse brain. Images were acquired at TOMCAT and SLS. All the images are the sum of MAX and MIN over 20 μm. Gray levels have been made consistent: white represents highest-density structures, black corresponds to less dense features.