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. 2020 Nov 23;24:653. doi: 10.1186/s13054-020-03375-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Kaplan–Meier plots of outcomes by initial dosing strategy of thromboprophylaxis. Kaplan–Meier plot of a 28-day survival, b thromboembolic events, and c bleeding events, among 152 patients admitted to the ICU due to COVID-19 between March 6 and April 30, 2020. By thromboprophylactic anticoagulant strategy with tinzaparin/dalteparin: The red line represent low-dose thromboprophylaxis (2500–4500 IU of tinzaparin daily, or 2500–5000 IU of dalteparin daily), the blue line represent medium-dose thromboprophylaxis (> 4500 IU to < 175 IU/kg of body weight of tinzaparin daily, or > 5000 IU to < 200 IU/kg of body weight of dalteparin daily), and the black line represent high-dose thromboprophylaxis (≥ 175 IU/kg of body weight of tinzaparin daily, or ≥ 200 IU/kg of body weight of dalteparin daily). Thromboembolic events in b are defined as pulmonary embolism, deep vein thrombosis, ischemic stroke, or peripheral arterial embolism. Hemorrhagic events in c are defined as grade 1–4 in the WHO bleeding scale