Table 1.

Binding free energy from docking analysis based on interaction of four different polypeptides with S-protein, receptor-binding domain (RBD) of S1, ACE2 receptor, and ACE2-lipopeptide complex with S1 protein

Interaction	Binding free energy with S1 protein (kcal)	Binding free energy with RBD of S1 (kcal)	Binding free energy with ACE2 (kcal)	Binding free energy of ACE2-lipopeptide complex with S1 protein (kcal)
Subtilisin	− 905.26	− 326.31	− 1250.28	− 849.01
Curvacin A	− 750.14	− 298.53	− 1352.01	− 857.30
Sakacin P	− 817.35	− 381.68	− 1180.43	− 600.09
Lactococcin Gb	− 654.24	− 253.56	− 1191.83	− 622.76